An in silico high-throughput screen identifies potential selective inhibitors for the non-receptor tyrosine kinase Pyk2

Tomer Meirson, Abraham O Samson, Hava Gil-Henn Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel Abstract: The non-receptor tyrosine kinase proline-rich tyrosine kinase 2 (Pyk2) is a critical mediator of signaling from cell surface growth factor and adhesion receptors to cell migration, proliferation, and survival.Emerging evid

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Innovative Nuclear Energy Systems: State-of-the Art Survey on Evaluation and Aggregation Judgment Measures Applied to Performance Comparison

This paper summarizes the experience gained in the application of multi-criteria decision making and uncertainty treatment methods to a comparative assessment of nuclear energy systems and related nuclear fuel cycles.These judgment measures provide a means for comprehensive evaluation according to different conflicting criteria, such as costs, bene

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